منابع مشابه
(Draft): Perceived User Benefits of Competing Ad-Blocking Strategies
Ad-blocking adoption has seen phenomenal levels of increase globally over the past several years. The advertising and technology industries have started to coalesce and respond to this threat by devising adblocking strategies that will block the most annoying forms of advertising by default. However, this approach only partially addresses the threats that Internet users perceive from online beh...
متن کاملThe substrate and anomeric specificity of fructokinase.
Fructokinase from beef liver is shown to be specific for the /3-furanose anomer of D-fructose (and the LY anomer of Lsorbose) by showing that certain 2,5-anhydroalditols are substrates, while other 2,5-anhydro compounds, 2,6-anhydro-D-mannitol, and 2,6-anhydro-D-glucitol are not. Km and Ir,,, values relative to D-fructose at pH 7.5, 25”, 4 mu MgATP are 2,5-anhydro-D-mannitol (1.7 mu, 1.97); 2,5...
متن کاملFructokinase (Fraction III) of Pea Seeds.
A second fructokinase (EC 2.7.1.4) was obtained from pea seed (Pisum sativum L. var. Progress No. 9) extracts. The enzyme, termed fructokinase (fraction III), was specific for fructose and had little activity with glucose. With fructose concentrations above 0.25 millimolar, there was strong substrate inhibition at the optimum pH (8.0) and also at pH 6.6. The apparent K(m) values at pH 8.0 for f...
متن کاملPurification and properties of rat liver fructokinase.
New spectrophotometric and radiochemical assay procedures for measuring fructoldnase (ATP:n-fructose l-phosphotransferase, EC 2.7.1.3) activity are reported. This enzyme has been purified from the liver of adult rats by acid and heat treatment, ammonium sulfate fractionation, and chromatography on Sephadex G-ZOO and diethylaminoethyl cellulose. The enzyme preparation has a specific activity of ...
متن کاملFructokinase activity mediates dehydration-induced renal injury
The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has been linked with recurrent dehydration. Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that might subsequently induce renal injury via metabolism by fructokinase. Wild-type and fructokinase-d...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2017
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2017.23